State of collagenolysis in experimental periodontitis of bacterial-immune genesis and its correction with flavonol

The article presents an assessment of the dynamics changes in content marker collagenolysis – free oxyproline homogeniate soft tissues and bone experimental bacterial-immune periodontitis elucidation effect flavonol quercetin on these indicators. aim this study was to determine role cytokinogenesis it pathogenesis, development course periodontitis. During experiment, a fragment mandible taken from animals, which were carefully separated. state collagen determined by tissues. concentration according calibration graph expressed μmol/g. results studies indicators biopolymers connective tissue structures periodontium 7th, 14th 30th day after its correction with (from 7th experiment) are presented. data nature monomers process formation inflammatory focus periodontal complex given. acute phase rats there revealed slight increase blood homogenate tissues, continued increase, at later stage namely day, resorption as compared day. disorders resulted pathological decrease level mandibular periodontium, same animals who did not receive use quercetin, which, affecting immune processes, limited response stabilized processes manifested homogenates animals.